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この研究成果の引用には次のURIを利用してください。: http://hdl.handle.net/10285/13558

種類: Thesis or Dissertation
タイトル: The Effectiveness of a Cardioverter Defibrillator in Patients with Cardiac Amyloidosis: A systematic literature review
タイトル別表記: 心アミロイドーシス患者における植込み型除細動器の有効性: システマティックレビュー
著者: 時岡, 紗由理
著者名ヨミ: トキオカ, サユリ
キーワード: amyloidosis
heart
implantable cardioverter defibrillator
ventricular tachycardia
ventricular fibrillation
sudden cardiac death
発行年月日: 2020年3月
抄録: Background: Amyloidosis is a rare disease caused by tissue deposition of protein fibrils. In case of cardiac involvement, it is called cardiac amyloidosis (CA), which has a poor prognosis and causes sudden cardiac death (SCD). An implantable cardioverter defibrillator (ICD) prevents SCD due to ventricular tachyarrhythmia; however, ICD implantation in patients with CA is controversial because of the poor prognosis of CA and the possibility of pulseless electrical activity. This study is a systematic review aimed to evaluate the efficacy of ICD in patients with CA. Methods: A systematic literature review was conducted in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA). On June 30, 2019, a comprehensive literature search of Medline, PubMed, Embase, CINAHL and the Cochrane Library was performed. Longitudinal observational studies of patients with CA with implanted ICD were included. Primary outcomes were appropriate ICD therapy, all-cause mortality and one-year survival. Results: Nine studies with a total of 704 CA patients with implanted ICD were included. The median incidence rate of appropriate ICD therapy was 26.0% (range 6.5-28.3%) of the patients during 21.5 (0-175) months of follow-up period. All-cause mortality was observed in 96 (41.3%) among 232 patients and median one-year survival was 79% (range 39-92%). Conclusions: Patients with CA benefit from ICD implantation considering the incidence rate of appropriate ICD therapy and one-year survival. There is no evidence that ICD implantation can 9 improve patients’ prognosis. Larger studies are needed to elucidate the impact of ICD on patients with CA and to develop selection criteria for implantation.
本文の種類: none
リンクURL: http://hdl.handle.net/10285/13558
出現コレクション:実践課題 - Capstone Project

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