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Please use this identifier to cite or link to this item: http://hdl.handle.net/10285/13553

NII Resource type: Thesis or Dissertation
Title: Predicting Severe Reactions in Oral Food Challenge from Blood Test Results in Children Who have Never Eaten the Suspected Food
Authors: 加藤, いづみ
Author-transcription: カトウ, イヅミ
Advisor: 高橋, 理
Keywords: oral food challenge
hen's eggs
ovomucoid-specific IgE
An investigating method or the measure : OFC: oral food challenge
OVM: ovomucoid
OVM-sIgE: ovomucoid-specific IgE
EW-sIgE: egg white-specific IgE
ROC: receiver operating characteristics
AUC: area under the curve
Issue Date: Mar-2020
Abstract: In daily practice of food allergies, it is common to see food elimination in children despite an incomplete diagnosis, for example, diagnosis made by the results of the blood test alone. Oral food challenge (OFC) is the most reliable test to diagnose food allergies. However, OFC also carries the risk of severe anaphylaxis. Factors that predict the outcomes of OFC have been reported. However, those specific to children who are on an elimination diet but have never eaten the suspected food have been scarcely investigated. This study aimed to identify factors that may help in predicting severe reactions in OFC from blood test results in children who have never eaten the suspected food. OFC performed in children from April 2013 to March 2018 in Chiba Kaihin Municipal Hospital was analyzed. The inclusion criteria to the OFC were children aged 0 to 15 years, children in whom eggs have been eliminated despite the use of limited diagnostic tests, and children who have never eaten the suspected food before the OFC. Age, sex, total IgE (tIgE), egg white-sIgE, and ovomucoid (OVM)-sIgE were analyzed in the severe reaction group [Total Score/Egg Protein (TS/Pro) ≥ 31] and non-severe reaction group (TS/Pro < 31). A total of 156 OFCs were analyzed. The OVM-sIgE level was significantly higher in the severe reaction group than in the non-severe reaction group. OVM-sgE may be useful for predicting severe reactions in OFC, particularly in those who have never eaten eggs.
The kind of text : none
URI: http://hdl.handle.net/10285/13553
Appears in Collections:実践課題 - Capstone Project

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